Abstract:  

We study a two-phase tumor growth model in two space dimensions, where proliferation of the tumor cells leads to expansion of the tumor domain and migration of surrounding normal tissues into the exterior vacuum. Instead of considering evolution of cell densities, our focus will be on the dynamics of two moving interfaces in the model that separate the tumor, the normal tissue, and the exterior vacuum. We will discuss well-posedness results on the interface evolution starting from a nearly radial initial configuration, under the assumption that the tumor has lower mobility than the normal tissue, which is in line with the well-known Saffman-Taylor condition in viscous fingering. We will briefly discuss possible ill-posedness scenarios when these conditions are violated, as well as implications of our results on further analysis of the tumor growth models. This is joint work with Inwon Kim.

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