Parameter Analysis in Yeast Cell Polarization and Stem Cell Lineages
Time: 2018-05-18
Published By: Xiaoni Tan
Speaker(s): Ching-Shan Chou (Ohio State University)
Time: 16:00-17:00 May 22, 2018
Venue: Room 29, Quan Zhai, BICMR
In systems biology, one of the biggest challenges is to estimate the parameters in the mathematical models. While some of the parameters can be measured through experiments, the majority of them cannot be obtained. While the choice of parameters is important in order to make meaningful and accurate predictions, the estimation of parameters can be based on the available data output. In this talk, I will present how we use a surrogate model to analyze the parameter sensitivity of the output as well as in the parameter inference. Two example systems, the yeast cell polarization and stem cell linage, will be discussed.
